Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice.

Crabbe J, Ozburn A, Hitzemann R, Spence S, Hack W, Schlumbohm J, Metten P.

Brain, Behavior, & Immunity - Health 2020 April Volume 4. https://doi.org/10.1016/j.bbih.2020.100061

Targeting the glucocorticoid receptor reduces binge-like drinking in High Drinking in the Dark (HDID-1) mice.

Savarese AM, Ozburn AR, Metten P, Schlumbohm JP, Hack WR, LeMoine K, Hunt H, Hausch F, Bauder M, Crabbe JC.

Alcohol Clin Exp Res. 2020 Mar 10. doi: 10.1111/acer.14318. [Epub ahead of print]  


Chronic chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes.

Pozhidayeva DY, Farris SP, Goeke CM, Firsick EJ, Townsley KG, Guizzetti M, Ozburn AR.

Brain Sci. 2020 Feb 18;10(2). pii: E109. doi: 10.3390/brainsci10020109.  

Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication. Ozburn AR, Metten P, Potretzke S, Townsley KG, Blednov YA, Crabbe JC.

Alcohol Clin Exp Res. 2020 Feb;44(2):553-566. doi: 10.1111/acer.14269. Epub 2020 Jan 13.  

Ethanol Conditioned Taste Aversion in High Drinking in the Dark Mice.

Crabbe JC, Metten P, Savarese AM, Ozburn AR, Schlumbohm JP, Spence SE, Hack WR.

Brain Sci. 2019 Jan 1;9(1). pii: E2. doi: 10.3390/brainsci9010002.

Pharmacogenetic manipulation of the nucleus accumbens alters binge-like alcohol drinking in mice.

Purohit K, Parekh PK, Kern J, Logan RW, Liu Z, Huang Y, McClung CA, Crabbe JC, Ozburn AR.

Alcoholism: Clinical and Experimental Research. 2018. In press. 


Genome-wide expression profiles drive discovery of novel compounds that reduce binge drinking in mice.

Ferguson LB*, Ozburn AR*, Ponomarev I, Metten P, Reilly M, Crabbe JC, Harris RA, Mayfield RD.

Neuropsychopharmacology. 2017. In press

NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors.

Ozburn AR, Kern J, Parekh PK, Logan RW, Liu Z, Falcon E, Becker-Krail D, Purohit K, Edgar NM, Huang Y, McClung CA.

Front Mol Neurosci. 2017 Nov 3;10:360. doi: 10.3389/fnmol.2017.00360. eCollection 2017.


High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking.

Crabbe JC*, Ozburn AR*, Metten P, Barkley-Levenson A, Schlumbohm JP, Spence SE, Hack WR, Huang LC.

Pharmacol Biochem Behav. 2017 Aug 5;160:55-62.

Functional Implications of the CLOCK 3111T/C Single-Nucleotide Polymorphism.

Ozburn AR, Purohit K, Parekh PK, Kaplan GN, Falcon E, Mukherjee S, Cates HM, McClung CA.

Front Psychiatry. 2016 Apr 21;7:67. 


Nest building is a novel method for indexing severity of alcohol withdrawal in mice.

Greenberg GD, Huang LC, Spence SE, Schlumbohm JP, Metten P, Ozburn AR, Crabbe JC.

Behav Brain Res. 2016 Apr 1;302:182-90.

Commonalities and distinctions among mechanisms of addiction to alcohol and other drugs.

Ozburn AR, Janowsky A, Crabbe J.

Alcoholism: Clinical and Experimental Research. 2015 Oct;39(10):1863-77.


Circadian clock genes: effects on dopamine, reward and addiction.

Parker PK*, Ozburn AR*, McClung CA.

Alcohol. 2015;49(4):341-9.


Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2.

Ozburn AR*, Falcon E*, Twaddle A, Nugent AL, Gillman AG, Spencer SM, Arey RN, Mukherjee S, Lyons-Weiler J, Self DW, McClung CA.

Biol Psychiatry. 2015;77(5):425-33.


Differential regulation of the period genes in striatal regions following cocaine exposure.

Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA.

PLoS One. 2013;8(6):e66438.


The role of clock in ethanol-related behaviors.

Ozburn AR, Falcon E, Mukherjee S, Gillman A, Arey R, Spencer S, McClung CA.

Neuropsychopharmacology. 2013;38(12):2393-400.


An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.

Arey RN, Enwright JF 3rd, Spencer SM, Falcon E, Ozburn AR, Ghose S, Tamminga C, McClung CA.

Mol Psychiatry. 2014;19(3):342-50. 


Chronic voluntary alcohol consumption results in tolerance to sedative/hypnotic and hypothermic effects of alcohol in hybrid mice.

Ozburn AR, Harris RA, Blednov YA.

Pharmacolology Biochemistry and Behavior. 2013;104:33-9.


Chronic self-administration of alcohol results in elevated ΔFosB: comparison of hybrid mice with distinct drinking patterns.

Ozburn AR, Mayfield RD, Ponomarev I, Jones TA, Blednov YA, Harris RA.

BMC Neuroscience. 2012;13:130.


Cocaine self-administration behaviors in ClockΔ19 mice.

Ozburn AR, Larson EB, Self DW, McClung CA.

Psychopharmacology (Berl). 2012;223(2):169-77.


Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania.

Coque L, Mukherjee S, Cao JL, Spencer S, Marvin M, Falcon E, Sidor MM, Birnbaum SG, Graham A, Neve RL, Gordon E, Ozburn AR, Goldberg MS, Han MH, Cooper DC, McClung CA.

Neuropsychopharmacology. 2011;36(7):1478-88.


The vermicelli and capellini handling tests: simple quantitative measures of dexterous forepaw function in rats and mice.

Tennant KA, Asay AL, Allred RP, Ozburn AR, Kleim JA, Jones TA.

Journal of Visualized Experiments. 2010;(41). pii: 2076.


Behavioral differences between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 hybrid mice: relation to control of ethanol intake.

Ozburn AR, Harris RA, Blednov YA.

Behavior Genetics. 2010;40(4):551-63.


Hybrid mice as genetic models of high alcohol consumption.

Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA.

Behavior Genetics. 2010 Jan;40(1):93-110.


Wheel running, voluntary ethanol consumption, and hedonic substitution.

Ozburn AR, Harris RA, Blednov YA.

Alcohol. 2008 Aug;42(5):417-24.


The structure of the minimal relaxase domain of MobA at 2.1 A resolution.

Monzingo AF, Ozburn A, Xia S, Meyer RJ, Robertus JD.

Journal of Molecular Biology. 2007;366(1):165-78.

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