Development and implementation of a Dependable, Simple, and Cost-effective (DSC), open-source running wheel in High Drinking in the Dark and Heterogeneous Stock/Northport mice.

Grigsby K, Usmani Z, Anderson J, Ozburn A.Front Behav Neurosci. 2024 Jan 15;17:1321349. doi: 10.3389/fnbeh.2023.1321349. eCollection 2023. PMID: 38288095  

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Modeling Brain Gene Expression in Alcohol Use Disorder with Genetic Animal Models.

Hitzemann R, Ozburn AR, Lockwood D, Phillips TJ.Curr Top Behav Neurosci. 2023 Nov 21. doi: 10.1007/7854_2023_455. Online ahead of print. PMID: 37982929

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Repurposing anti-inflammatory medications for alcohol and substance use disorders.

Ozburn AR, Spencer SM.Neuropsychopharmacology. 2024 Jan;49(1):317-318. doi: 10.1038/s41386-023-01696-z.PMID: 37550437.

 

Preclinical and clinical evidence for suppression of alcohol intake by apremilast.

Grigsby KB, Mangieri RA, Roberts AJ, Lopez MF, Firsick EJ, Townsley KG, Beneze A, Bess J, Eisenstein TK, Meissler JJ, Light JM, Miller J, Quello S, Shadan F, Skinner M, Aziz HC, Metten P, Morrisett RA, Crabbe JC, Roberto M, Becker HC, Mason BJ, Ozburn AR.J Clin Invest. 2023 Mar 15;133(6):e159103. doi: 10.1172/JCI159103.PMID: 36656645 

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Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression.

Grigsby K, Ledford C, Batish T, Kanadibhotla S, Smith D, Firsick E, Tran A, Townsley K, Reyes KV, LeBlanc K, Ozburn A.Int J Mol Sci. 2022 Sep 21;23(19):11084. doi: 10.3390/ijms231911084.PMID: 36232380

 

Brain gene expression differences related to ethanol preference in the collaborative cross founder strains.

Anderson JQ, Darakjian P, Hitzemann R, Lockwood DR, Phillips TJ, Ozburn AR.Front Behav Neurosci. 2022 Sep 23;16:992727. doi: 10.3389/fnbeh.2022.992727. PMID: 36212197 

 

Midazolam, methamphetamine, morphine and nicotine intake in high-drinking-in-the-dark mice.

Savarese AM, Metten P, Phillips TJ, Jensen BE, Crabbe JC, Ozburn AR.Addict Biol. 2022 Sep;27(5):e13212. doi: 10.1111/adb.13212.PMID: 36001437

 

Corticosterone Levels and Glucocorticoid Receptor Gene Expression in High Drinking in the Dark Mice and Their Heterogeneous Stock (HS/NPT) Founder Line.

Savarese AM, Grigsby KB, Jensen BE, Borrego MB, Finn DA, Crabbe JC, Ozburn AR.Front Behav Neurosci. 2022 May 12;16:821859. doi: 10.3389/fnbeh.2022.821859. PMID: 35645743

 

Regulation of alcohol drinking by ventral striatum and extended amygdala circuitry.

Borrego MB, Chan AE, Ozburn AR.Neuropharmacology. 2022 Jul 1;212:109074. doi: 10.1016/j.neuropharm.2022.109074. PMID: 35487273

 

Central nucleus of the amygdala projections onto the nucleus accumbens core regulate binge-like alcohol drinking in a CRF-dependent manner.

Borrego MB, Grigsby KB, Townsley KG, Chan A, Firsick EJ, Tran A, Savarese A, Ozburn AR.Neuropharmacology. 2022 Feb 1;203:108874. doi: 10.1016/j.neuropharm.2021.108874. PMID: 34748860

 

On the Use of Heterogeneous Stock Mice to Map Transcriptomes Associated With Excessive Ethanol Consumption.

Hitzemann R, Lockwood DR, Ozburn AR, Phillips TJ.Front Psychiatry. 2021 Oct 12;12:725819. doi: 10.3389/fpsyt.2021.725819. PMID: 34712155  

 

Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder.

Hitzemann R, Bergeson SE, Berman AE, Bubier JA, Chesler EJ, Finn DA, Hein M, Hoffman P, Holmes A, Kisby BR, Lockwood D, Lodowski KH, McManus M, Owen JA, Ozburn AR, Panthagani P, Ponomarev I, Saba L, Tabakoff B, Walchale A, Williams RW, Phillips TJ.Biol Psychiatry. 2022 Jan 1;91(1):43-52. doi: 10.1016/j.biopsych.2021.04.016. PMID: 34274109 

 

Long-term alcohol drinking in High Drinking in the Dark mice is stable for many months and does not show alcohol deprivation effects.

Crabbe JC, Hack WR, Ozburn AR, Savarese AM, Metten P.Addict Biol. 2022 Jan;27(1):e13074. doi: 10.1111/adb.13074. PMID: 34227188

 

Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication.

Jensen BE, Townsley KG, Grigsby KB, Metten P, Chand M, Uzoekwe M, Tran A, Firsick E, LeBlanc K, Crabbe JC, Ozburn AR.Brain Sci. 2021 Feb 4;11(2):189. doi: 10.3390/brainsci11020189.PMID: 33557285 

 

The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice.

Savarese AM, Ozburn AR, Barkley-Levenson AM, Metten P, Crabbe JC.Alcohol. 2021 Jun;93:45-56. doi: 10.1016/j.alcohol.2021.02.001. PMID: 33556460 

 

Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice.

Grigsby KB, Savarese AM, Metten P, Mason BJ, Blednov YA, Crabbe JC, Ozburn AR.Neurosci Insights. 2020 Nov 25;15:2633105520975412. doi: 10.1177/2633105520975412. eCollection 2020. PMID: 33294845 

 

Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2.

Logan RW, Ozburn AR, Arey RN, Ketchesin KD, Winquist A, Crain A, Tobe BTD, Becker-Krail D, Jarpe MB, Xue X, Zong W, Huo Z, Parekh PK, Zhu X, Fitzgerald E, Zhang H, Oliver-Smith J, DePoy LM, Hildebrand MA, Snyder EY, Tseng GC, McClung CA.Mol Psychiatry. 2021 Aug;26(8):4066-4084. doi: 10.1038/s41380-020-00958-2. PMID: 33235333 

 

Effects of chemogenetic manipulation of the nucleus accumbens core in male C57BL/6J mice.

Townsley KG, Borrego MB, Ozburn AR.Alcohol. 2021 Mar;91:21-27. doi: 10.1016/j.alcohol.2020.10.005. PMID: 33160072 

 

Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice.

Crabbe JC, Ozburn AR, Hitzemann RJ, Spence SE, Hack WR, Schlumbohm JP, Metten P.Brain Behav Immun Health. 2020 Mar 19;4:100061. doi: 10.1016/j.bbih.2020.100061. PMID: 34589846 

 

Targeting the Glucocorticoid Receptor Reduces Binge-Like Drinking in High Drinking in the Dark (HDID-1) Mice.

Savarese AM, Ozburn AR, Metten P, Schlumbohm JP, Hack WR, LeMoine K, Hunt H, Hausch F, Bauder M, Crabbe JC.Alcohol Clin Exp Res. 2020 May;44(5):1025-1036. doi: 10.1111/acer.14318. PMID: 32154593  

 

Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes.

Pozhidayeva DY, Farris SP, Goeke CM, Firsick EJ, Townsley KG, Guizzetti M, Ozburn AR.Brain Sci. 2020 Feb 18;10(2):109. doi: 10.3390/brainsci10020109.PMID: 32085427  

 

Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication.

Ozburn AR, Metten P, Potretzke S, Townsley KG, Blednov YA, Crabbe JC.Alcohol Clin Exp Res. 2020 Feb;44(2):553-566. doi: 10.1111/acer.14269. PMID: 31853996  

 

Ethanol Conditioned Taste Aversion in High Drinking in the Dark Mice.

Crabbe JC, Metten P, Savarese AM, Ozburn AR, Schlumbohm JP, Spence SE, Hack WR.Brain Sci. 2019 Jan 1;9(1):2. doi: 10.3390/brainsci9010002.PMID: 30609665  

 

Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge-Like Alcohol Drinking in Mice.

Purohit K, Parekh PK, Kern J, Logan RW, Liu Z, Huang Y, McClung CA, Crabbe JC, Ozburn AR.Alcohol Clin Exp Res. 2018 May;42(5):879-888. doi: 10.1111/acer.13626. PMID: 29668112  

 

Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice.

Ferguson LB, Ozburn AR, Ponomarev I, Metten P, Reilly M, Crabbe JC, Harris RA, Mayfield RD.Neuropsychopharmacology. 2018 May;43(6):1257-1266. doi: 10.1038/npp.2017.301. PMID: 29251283 

 

NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors.

Ozburn AR, Kern J, Parekh PK, Logan RW, Liu Z, Falcon E, Becker-Krail D, Purohit K, Edgar NM, Huang Y, McClung CA.Front Mol Neurosci. 2017 Nov 3;10:360. doi: 10.3389/fnmol.2017.00360. PMID: 29163035 

 

High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking.

Crabbe JC, Ozburn AR, Metten P, Barkley-Levenson A, Schlumbohm JP, Spence SE, Hack WR, Huang LC.Pharmacol Biochem Behav. 2017 Sep;160:55-62. doi: 10.1016/j.pbb.2017.08.002. PMID: 28827047 

 

Functional Implications of the CLOCK 3111T/C Single-Nucleotide Polymorphism.

Ozburn AR, Purohit K, Parekh PK, Kaplan GN, Falcon E, Mukherjee S, Cates HM, McClung CA.Front Psychiatry. 2016 Apr 21;7:67. doi: 10.3389/fpsyt.2016.00067. PMID: 27148095 

 

Nest building is a novel method for indexing severity of alcohol withdrawal in mice.

Greenberg GD, Huang LC, Spence SE, Schlumbohm JP, Metten P, Ozburn AR, Crabbe JC.Behav Brain Res. 2016 Apr 1;302:182-90. doi: 10.1016/j.bbr.2016.01.023. PMID: 26795092 

 

Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs.

Ozburn AR, Janowsky AJ, Crabbe JC.Alcohol Clin Exp Res. 2015 Oct;39(10):1863-77. doi: 10.1111/acer.12810.PMID: 26431116  

 

Circadian clock genes: effects on dopamine, reward and addiction.

Parekh PK, Ozburn AR, McClung CA.Alcohol. 2015 Jun;49(4):341-9. doi: 10.1016/j.alcohol.2014.09.034. PMID: 25641765  

 

Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2.

Ozburn AR, Falcon E, Twaddle A, Nugent AL, Gillman AG, Spencer SM, Arey RN, Mukherjee S, Lyons-Weiler J, Self DW, McClung CA.Biol Psychiatry. 2015 Mar 1;77(5):425-433. doi: 10.1016/j.biopsych.2014.07.030. PMID: 25444159  

 

Differential regulation of the period genes in striatal regions following cocaine exposure.

Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA.PLoS One. 2013 Jun 11;8(6):e66438. doi: 10.1371/journal.pone.0066438. Print 2013. PMID: 23776671  

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The role of clock in ethanol-related behaviors.

Ozburn AR, Falcon E, Mukherjee S, Gillman A, Arey R, Spencer S, McClung CA.Neuropsychopharmacology. 2013 Nov;38(12):2393-400. doi: 10.1038/npp.2013.138. PMID: 23722243

 

An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.

Arey RN, Enwright JF 3rd, Spencer SM, Falcon E, Ozburn AR, Ghose S, Tamminga C, McClung CA.Mol Psychiatry. 2014 Mar;19(3):342-50. doi: 10.1038/mp.2013.12. PMID: 23399917 

 

Chronic voluntary alcohol consumption results in tolerance to sedative/hypnotic and hypothermic effects of alcohol in hybrid mice.

Ozburn AR, Harris RA, Blednov YA.Pharmacol Biochem Behav. 2013 Mar;104:33-9. doi: 10.1016/j.pbb.2012.12.025. PMID: 23313769  

  

Chronic self-administration of alcohol results in elevated ΔFosB: comparison of hybrid mice with distinct drinking patterns.

Ozburn AR, Mayfield RD, Ponomarev I, Jones TA, Blednov YA, Harris RA.BMC Neurosci. 2012 Oct 29;13:130. doi: 10.1186/1471-2202-13-130.PMID: 23102405  

 

Cocaine self-administration behaviors in ClockΔ19 mice.

Ozburn AR, Larson EB, Self DW, McClung CA.Psychopharmacology (Berl). 2012 Sep;223(2):169-77. doi: 10.1007/s00213-012-2704-2. Epub 2012 Apr 26.PMID: 22535308  

 

Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania.

Coque L, Mukherjee S, Cao JL, Spencer S, Marvin M, Falcon E, Sidor MM, Birnbaum SG, Graham A, Neve RL, Gordon E, Ozburn AR, Goldberg MS, Han MH, Cooper DC, McClung CA.Neuropsychopharmacology. 2011 Jun;36(7):1478-88. doi: 10.1038/npp.2011.33. PMID: 21430648  

 

The vermicelli and capellini handling tests: simple quantitative measures of dexterous forepaw function in rats and mice.

Tennant KA, Asay AL, Allred RP, Ozburn AR, Kleim JA, Jones TA.J Vis Exp. 2010 Jul 21;(41):2076. doi: 10.3791/2076. PMID: 20689506  

 

Behavioral differences between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 hybrid mice: relation to control of ethanol intake.

Ozburn AR, Harris RA, Blednov YA.Behav Genet. 2010 Jul;40(4):551-63. doi: 10.1007/s10519-010-9357-x.  PMID: 20364436  

 

Hybrid mice as genetic models of high alcohol consumption.

Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA.Behav Genet. 2010 Jan;40(1):93-110. doi: 10.1007/s10519-009-9298-4. PMID: 19798565  

 

Wheel running, voluntary ethanol consumption, and hedonic substitution.

Ozburn AR, Harris RA, Blednov YA.Alcohol. 2008 Aug;42(5):417-24. doi: 10.1016/j.alcohol.2008.04.006. PMID: 18579336 

 

The structure of the minimal relaxase domain of MobA at 2.1 A resolution.

Monzingo AF, Ozburn A, Xia S, Meyer RJ, Robertus JD.J Mol Biol. 2007 Feb 9;366(1):165-78. doi: 10.1016/j.jmb.2006.11.031. PMID: 17157875