Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression.

Grigsby K, Ledford C, Batish T, Kanadibhotla S, Smith D, Firsick E, Tran A, Townsley K, Reyes KV, LeBlanc K, Ozburn A.Int J Mol Sci. 2022 Sep 21;23(19):11084. doi: 10.3390/ijms231911084.PMID: 36232380 Free PMC article.

 

Brain gene expression differences related to ethanol preference in the collaborative cross founder strains.

Anderson JQ, Darakjian P, Hitzemann R, Lockwood DR, Phillips TJ, Ozburn AR.Front Behav Neurosci. 2022 Sep 23;16:992727. doi: 10.3389/fnbeh.2022.992727. eCollection 2022.PMID: 36212197 Free PMC article.

 

Midazolam, methamphetamine, morphine and nicotine intake in high-drinking-in-the-dark mice.

Savarese AM, Metten P, Phillips TJ, Jensen BE, Crabbe JC, Ozburn AR.Addict Biol. 2022 Sep;27(5):e13212. doi: 10.1111/adb.13212.PMID: 36001437

 

Corticosterone Levels and Glucocorticoid Receptor Gene Expression in High Drinking in the Dark Mice and Their Heterogeneous Stock (HS/NPT) Founder Line.

Savarese AM, Grigsby KB, Jensen BE, Borrego MB, Finn DA, Crabbe JC, Ozburn AR.Front Behav Neurosci. 2022 May 12;16:821859. doi: 10.3389/fnbeh.2022.821859. eCollection 2022.PMID: 35645743 Free PMC article.

 

Regulation of alcohol drinking by ventral striatum and extended amygdala circuitry.

Borrego MB, Chan AE, Ozburn AR.Neuropharmacology. 2022 Jul 1;212:109074. doi: 10.1016/j.neuropharm.2022.109074. Epub 2022 Apr 26.PMID: 35487273 Review.

 

Central nucleus of the amygdala projections onto the nucleus accumbens core regulate binge-like alcohol drinking in a CRF-dependent manner.

Borrego MB, Grigsby KB, Townsley KG, Chan A, Firsick EJ, Tran A, Savarese A, Ozburn AR.Neuropharmacology. 2022 Feb 1;203:108874. doi: 10.1016/j.neuropharm.2021.108874. Epub 2021 Nov 5.PMID: 34748860

 

On the Use of Heterogeneous Stock Mice to Map Transcriptomes Associated With Excessive Ethanol Consumption.

Hitzemann R, Lockwood DR, Ozburn AR, Phillips TJ.Front Psychiatry. 2021 Oct 12;12:725819. doi: 10.3389/fpsyt.2021.725819. eCollection 2021.PMID: 34712155 Free PMC article. Review.

 

Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder.

Hitzemann R, Bergeson SE, Berman AE, Bubier JA, Chesler EJ, Finn DA, Hein M, Hoffman P, Holmes A, Kisby BR, Lockwood D, Lodowski KH, McManus M, Owen JA, Ozburn AR, Panthagani P, Ponomarev I, Saba L, Tabakoff B, Walchale A, Williams RW, Phillips TJ.Biol Psychiatry. 2022 Jan 1;91(1):43-52. doi: 10.1016/j.biopsych.2021.04.016. Epub 2021 May 1.PMID: 34274109 Review.

 

Long-term alcohol drinking in High Drinking in the Dark mice is stable for many months and does not show alcohol deprivation effects.

Crabbe JC, Hack WR, Ozburn AR, Savarese AM, Metten P.Addict Biol. 2022 Jan;27(1):e13074. doi: 10.1111/adb.13074. Epub 2021 Jul 5.PMID: 34227188

 

Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication.

Jensen BE, Townsley KG, Grigsby KB, Metten P, Chand M, Uzoekwe M, Tran A, Firsick E, LeBlanc K, Crabbe JC, Ozburn AR.Brain Sci. 2021 Feb 4;11(2):189. doi: 10.3390/brainsci11020189.PMID: 33557285 Free PMC article.

 

The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice.

Savarese AM, Ozburn AR, Barkley-Levenson AM, Metten P, Crabbe JC.Alcohol. 2021 Jun;93:45-56. doi: 10.1016/j.alcohol.2021.02.001. Epub 2021 Feb 6.PMID: 33556460 Free PMC article.

 

Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice.

Grigsby KB, Savarese AM, Metten P, Mason BJ, Blednov YA, Crabbe JC, Ozburn AR.Neurosci Insights. 2020 Nov 25;15:2633105520975412. doi: 10.1177/2633105520975412. eCollection 2020.PMID: 33294845 Free PMC article.

 

Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2.

Logan RW, Ozburn AR, Arey RN, Ketchesin KD, Winquist A, Crain A, Tobe BTD, Becker-Krail D, Jarpe MB, Xue X, Zong W, Huo Z, Parekh PK, Zhu X, Fitzgerald E, Zhang H, Oliver-Smith J, DePoy LM, Hildebrand MA, Snyder EY, Tseng GC, McClung CA.Mol Psychiatry. 2021 Aug;26(8):4066-4084. doi: 10.1038/s41380-020-00958-2. Epub 2020 Nov 24.PMID: 33235333 Free PMC article.

 

Effects of chemogenetic manipulation of the nucleus accumbens core in male C57BL/6J mice.

Townsley KG, Borrego MB, Ozburn AR.Alcohol. 2021 Mar;91:21-27. doi: 10.1016/j.alcohol.2020.10.005. Epub 2020 Nov 4.PMID: 33160072 Free PMC article.

 

Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice.

Crabbe JC, Ozburn AR, Hitzemann RJ, Spence SE, Hack WR, Schlumbohm JP, Metten P.Brain Behav Immun Health. 2020 Mar 19;4:100061. doi: 10.1016/j.bbih.2020.100061. eCollection 2020 Apr.PMID: 34589846 Free PMC article.

 

Targeting the Glucocorticoid Receptor Reduces Binge-Like Drinking in High Drinking in the Dark (HDID-1) Mice.

Savarese AM, Ozburn AR, Metten P, Schlumbohm JP, Hack WR, LeMoine K, Hunt H, Hausch F, Bauder M, Crabbe JC.Alcohol Clin Exp Res. 2020 May;44(5):1025-1036. doi: 10.1111/acer.14318. Epub 2020 Mar 27.PMID: 32154593 Free PMC article.

 

Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes.

Pozhidayeva DY, Farris SP, Goeke CM, Firsick EJ, Townsley KG, Guizzetti M, Ozburn AR.Brain Sci. 2020 Feb 18;10(2):109. doi: 10.3390/brainsci10020109.PMID: 32085427 Free PMC article.

 

Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication.

Ozburn AR, Metten P, Potretzke S, Townsley KG, Blednov YA, Crabbe JC.Alcohol Clin Exp Res. 2020 Feb;44(2):553-566. doi: 10.1111/acer.14269. Epub 2020 Jan 13.PMID: 31853996 Free PMC article.

 

Ethanol Conditioned Taste Aversion in High Drinking in the Dark Mice.

Crabbe JC, Metten P, Savarese AM, Ozburn AR, Schlumbohm JP, Spence SE, Hack WR.Brain Sci. 2019 Jan 1;9(1):2. doi: 10.3390/brainsci9010002.PMID: 30609665 Free PMC article.

 

Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge-Like Alcohol Drinking in Mice.

Purohit K, Parekh PK, Kern J, Logan RW, Liu Z, Huang Y, McClung CA, Crabbe JC, Ozburn AR.Alcohol Clin Exp Res. 2018 May;42(5):879-888. doi: 10.1111/acer.13626. Epub 2018 Apr 18.PMID: 29668112 Free PMC article.

 

Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice.

Ferguson LB, Ozburn AR, Ponomarev I, Metten P, Reilly M, Crabbe JC, Harris RA, Mayfield RD.Neuropsychopharmacology. 2018 May;43(6):1257-1266. doi: 10.1038/npp.2017.301. Epub 2017 Dec 18.PMID: 29251283 Free PMC article.

 

NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors.

Ozburn AR, Kern J, Parekh PK, Logan RW, Liu Z, Falcon E, Becker-Krail D, Purohit K, Edgar NM, Huang Y, McClung CA.Front Mol Neurosci. 2017 Nov 3;10:360. doi: 10.3389/fnmol.2017.00360. eCollection 2017.PMID: 29163035 Free PMC article.

 

High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking.

Crabbe JC, Ozburn AR, Metten P, Barkley-Levenson A, Schlumbohm JP, Spence SE, Hack WR, Huang LC.Pharmacol Biochem Behav. 2017 Sep;160:55-62. doi: 10.1016/j.pbb.2017.08.002. Epub 2017 Aug 5.PMID: 28827047 Free PMC article.

 

Functional Implications of the CLOCK 3111T/C Single-Nucleotide Polymorphism.

Ozburn AR, Purohit K, Parekh PK, Kaplan GN, Falcon E, Mukherjee S, Cates HM, McClung CA.Front Psychiatry. 2016 Apr 21;7:67. doi: 10.3389/fpsyt.2016.00067. eCollection 2016.PMID: 27148095 Free PMC article.

 

Nest building is a novel method for indexing severity of alcohol withdrawal in mice.

Greenberg GD, Huang LC, Spence SE, Schlumbohm JP, Metten P, Ozburn AR, Crabbe JC.Behav Brain Res. 2016 Apr 1;302:182-90. doi: 10.1016/j.bbr.2016.01.023. Epub 2016 Jan 12.PMID: 26795092 Free PMC article.

 

Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs.

Ozburn AR, Janowsky AJ, Crabbe JC.Alcohol Clin Exp Res. 2015 Oct;39(10):1863-77. doi: 10.1111/acer.12810.PMID: 26431116 Free PMC article. Review.

 

Circadian clock genes: effects on dopamine, reward and addiction.

Parekh PK, Ozburn AR, McClung CA.Alcohol. 2015 Jun;49(4):341-9. doi: 10.1016/j.alcohol.2014.09.034. Epub 2015 Jan 8.PMID: 25641765 Free PMC article. Review.

 

Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2.

Ozburn AR, Falcon E, Twaddle A, Nugent AL, Gillman AG, Spencer SM, Arey RN, Mukherjee S, Lyons-Weiler J, Self DW, McClung CA.Biol Psychiatry. 2015 Mar 1;77(5):425-433. doi: 10.1016/j.biopsych.2014.07.030. Epub 2014 Aug 13.PMID: 25444159 Free PMC article.

 

Differential regulation of the period genes in striatal regions following cocaine exposure.

Falcon E, Ozburn A, Mukherjee S, Roybal K, McClung CA.PLoS One. 2013 Jun 11;8(6):e66438. doi: 10.1371/journal.pone.0066438. Print 2013.PMID: 23776671 Free PMC article.

 

The role of clock in ethanol-related behaviors.

Ozburn AR, Falcon E, Mukherjee S, Gillman A, Arey R, Spencer S, McClung CA.Neuropsychopharmacology. 2013 Nov;38(12):2393-400. doi: 10.1038/npp.2013.138. Epub 2013 May 31.PMID: 23722243 Free PMC article.

 

An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.

Arey RN, Enwright JF 3rd, Spencer SM, Falcon E, Ozburn AR, Ghose S, Tamminga C, McClung CA.Mol Psychiatry. 2014 Mar;19(3):342-50. doi: 10.1038/mp.2013.12. Epub 2013 Feb 12.PMID: 23399917 Free PMC article.

 

Chronic voluntary alcohol consumption results in tolerance to sedative/hypnotic and hypothermic effects of alcohol in hybrid mice.

Ozburn AR, Harris RA, Blednov YA.Pharmacol Biochem Behav. 2013 Mar;104:33-9. doi: 10.1016/j.pbb.2012.12.025. Epub 2013 Jan 8.PMID: 23313769 Free PMC article.

  

Chronic self-administration of alcohol results in elevated ΔFosB: comparison of hybrid mice with distinct drinking patterns.

Ozburn AR, Mayfield RD, Ponomarev I, Jones TA, Blednov YA, Harris RA.BMC Neurosci. 2012 Oct 29;13:130. doi: 10.1186/1471-2202-13-130.PMID: 23102405 Free PMC article.

 

Cocaine self-administration behaviors in ClockΔ19 mice.

Ozburn AR, Larson EB, Self DW, McClung CA.Psychopharmacology (Berl). 2012 Sep;223(2):169-77. doi: 10.1007/s00213-012-2704-2. Epub 2012 Apr 26.PMID: 22535308 Free PMC article.

 

Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania.

Coque L, Mukherjee S, Cao JL, Spencer S, Marvin M, Falcon E, Sidor MM, Birnbaum SG, Graham A, Neve RL, Gordon E, Ozburn AR, Goldberg MS, Han MH, Cooper DC, McClung CA.Neuropsychopharmacology. 2011 Jun;36(7):1478-88. doi: 10.1038/npp.2011.33. Epub 2011 Mar 23.PMID: 21430648 Free PMC article.

 

The vermicelli and capellini handling tests: simple quantitative measures of dexterous forepaw function in rats and mice.

Tennant KA, Asay AL, Allred RP, Ozburn AR, Kleim JA, Jones TA.J Vis Exp. 2010 Jul 21;(41):2076. doi: 10.3791/2076.PMID: 20689506 Free PMC article.

 

Behavioral differences between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 hybrid mice: relation to control of ethanol intake.

Ozburn AR, Harris RA, Blednov YA.Behav Genet. 2010 Jul;40(4):551-63. doi: 10.1007/s10519-010-9357-x. Epub 2010 Apr 4.PMID: 20364436 Free PMC article.

 

Hybrid mice as genetic models of high alcohol consumption.

Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA.Behav Genet. 2010 Jan;40(1):93-110. doi: 10.1007/s10519-009-9298-4. Epub 2009 Oct 2.PMID: 19798565 Free PMC article.

 

Wheel running, voluntary ethanol consumption, and hedonic substitution.

Ozburn AR, Harris RA, Blednov YA.Alcohol. 2008 Aug;42(5):417-24. doi: 10.1016/j.alcohol.2008.04.006. Epub 2008 Jun 24.PMID: 18579336 Free PMC article.

 

The structure of the minimal relaxase domain of MobA at 2.1 A resolution.

Monzingo AF, Ozburn A, Xia S, Meyer RJ, Robertus JD.J Mol Biol. 2007 Feb 9;366(1):165-78. doi: 10.1016/j.jmb.2006.11.031. Epub 2006 Nov 11.PMID: 17157875 Free PMC article.